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By admin, September 18, 2010 10:10 PM

A recent paper in the journal Science provides some evidence that Aβ can, like the prion protein, initiate the nucleation-polymerization in cells into which it is introduced.

Meyer-Luehmann, et al used two strains of transgenic mice in their experiments. Mice of one strain (APP23) over-produce the 40-amino-acid Aβ peptide, while mice of the other strain (APPPS1) over-produce the 42-amino acid peptide. In both strains, Aβ plaques are deposited in the brain as the animals age, but the strains differ in the distribution and appearance of the plaques.

The experiments involved taking brain extracts from deceased Alzheimer’s patients or from aged mice of both strains, and injected them into the brains of young mice of both strains, before they had developed the symptoms of the disease. It was observed that all extracts had a seeding activity in both strains of mice – they induced the deposition of the Aβ peptide, which aggregated to form plaques in the brains of the mice into which they had been injected. The seeding activity was both time- and concentration-dependent (i.e. seeding increased with time, and with greater concentrations of Aβ in the extracts), but differed depending on the strain of mouse the extract was taken from, and the strain it was injected into.

However, if the extracts were treated with anti-Aβ antibodies, or heated so that the structure of the Aβ molecules was destroyed, the seeding activity was abolished. Similarly, if the host mice were immunized against Aβ before they were injected with the extracts, seeding did not occur. Finally, no seeding activity was observed when any brain extract was injected into the brain of normal mice, suggesting that, if Alzheimer’s was indeed found to be infectious, an infected individual would have to be genetically predisposed to the condition in order for it to develop.

One could predict that the accumulation of abnormal proteins in other neurodegenerative diseases – e.g. alpha-synuclein in Parkinson’s Disease and huntingtin in Huntington’s Disease, may also occur as a result of a prion-like seeding process. But for me, the most puzzling question of all is this: how would an Alzheimer’s infection be transmitted?

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By admin, September 4, 2010 6:40 PM

HERE ARE THE AUSTRALIAN SETTINGS FOR THE LINKSYS 3102

AND ALSO THE FAX SETTINGS TO MAKE FAXING WORK ON VOIP

AUSTRALIAN SETTINGS

Dial tone: 400@-19,425@-19,450@-19;10(*/0/1+2+3)

Busy Tone: 425@-19;10(.375/.375/1)

Reorder Tone: 425@-19,425@-29;60(.375/.375/1,.375/.375/2)

Ring Back Tone: 400@-19,425@-19,450@-19;*(.4/.2/1+2+3,.4/2/1+2+3)

MWI Dial Tone: 400@-19,425@-19,450@-19;2(.1/.1/1+2);10(*/0/1+2)

Ring1 Cadence: 60(.4/.2,.4/2)

 

FXS Port Impedence: 220+820||115nF
DTMF Playback Length: .25
Time Zone: GMT+10:00

PSTN

Disconnect Tone: 425@-30,425@-30;1(.375/.375/1+2)
 FXO Port Impedance: 220+820||120nF
 PSTN to SPA Gain: 3
 On-Hook Speed: 26ms (Australia)

DIAL PLAN
JUST A NOTE NOT DIAL PLAN NO WORKIE

([2-79]11<:@gw0>|xx.|*xx.|**xx.|<#,:>xx.<:@gw0>|<#,:>*xx<:@gw0>)

FAX 3102 SETTINGS

a) Network Jitter Level – Very High (was medium)
b) Jitter Buffer Adjustment – Disable (was up down)

c) “Call Waiting Serv” : Set this to No
d) “Three Way Call Serv” : Set this to No as well.

a) Set the PreferredCodec to G711u
b) Set “Silence Suppression Enable” to No
c) Make sure that the option FAX Enable T38 is set to Yes. (Default setting is Yes)
d) “Echo Canc Enable” should be set to No
e) Set the option “Fax Passthru Method” to REINVITES.

more infro

https://docs.google.com/View?docid=dmqx96v_3qk8phn

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By admin, August 31, 2010 7:31 PM

mysql too many connections

go to my.ini

max_connections=500

Please note that an instruction of the form
set-variable=max_connections=500
should be placed in the [mysqld] section. Otherwise MySQL will ignore it.

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By admin, August 14, 2010 9:17 PM

CREATE USER ‘monty’@'%’ IDENTIFIED BY ‘some_pass’;
GRANT ALL PRIVILEGES ON *.* TO ‘monty’@'%’
WITH GRANT OPTION;

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By admin, August 14, 2010 7:57 PM

[global]
log file = /var/log/samba/log.%m
load printers = no
smb passwd file = /etc/samba/smbpasswd
browseable = no
server string = trixbox PBX
path = /
workgroup = workgroup
os level = 2000
username map = /etc/samba/smbusers
preferred master = no
max log size = 50

[share]
browseable = yes
writeable = yes
write list = root
comment = server
valid users = root
path = /
public = yes

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By admin, August 14, 2010 7:46 PM

system-config-network

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By admin, August 14, 2010 7:34 PM

make a DB in mysql
login to mysql
mysql -u root -p
then
CREATE DATABASE `openfire`;
CREATE USER ‘openfire’@'localhost’ IDENTIFIED BY ‘password’;
GRANT USAGE ON *.* TO ‘openfire’@'localhost’ IDENTIFIED BY ‘password’ WITH MAX_QUERIES_PER_HOUR 0 MAX_CONNECTIONS_PER_HOUR 0 MAX_UPDATES_PER_HOUR 0 MAX_USER_CONNECTIONS 0;
GRANT SELECT, INSERT, UPDATE, DELETE, CREATE, DROP, INDEX, ALTER, CREATE TEMPORARY TABLES ON `openfire`.* TO ‘openfire’@'localhost’;
FLUSH PRIVILEGES;
quit

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By admin, August 12, 2010 7:35 PM

find your CPU architecture
cat /proc/cpuinfo

Goto

http://asterisk.hosting.lv/

DL the right one
# choose codec binary appropriate for your Asterisk version and CPU type, use x86_64 for 64-bit mode, scroll to the end of the list for FreeBSD binaries
# delete old codec_g729/723*.so files (if any) from /usr/lib/asterisk/modules directory
# copy new codec_g729/723*.so files into /usr/lib/asterisk/modules directory
# restart Asterisk

Then connect to the Asterisk console with:
asterisk -r
and type (adjust accordingly):
load codec_g729-ast14-gcc4-glibc-core2.so

You should then see something like:
Loaded /usr/lib/asterisk/modules/codec_g729-ast14-gcc4-glibc-core2.so => (G729/PCM16 (signed linear) Codec Translator, based on IPP)
== Registered translator ‘g729tolin’ from format g729 to slin, cost 1
== Registered translator ‘lintog729′ from format slin to g729, cost 6

Exit from the console with:
quit

Then use nano to edit /etc/asterisk/sip.conf and just below:
allow=ulaw
add:
allow=gsm
allow=g729

# check the codec is loaded with ‘core show translation recalc 10′ on Asterisk console (‘show translation’ in Asterisk 1.2)
# G.723.1 send rate is configured in Asterisk codecs.conf file (Linux Asterisk 1.2, 1.4, 1.6, TRUNK and Callweaver, FreeBSD 7.x Asterisk 1.4 binaries only):

other cool linux commands

cat /proc/cpuinfo
cat /proc/meminfo
dmesg
lspci

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By admin, July 30, 2010 8:50 PM

Hi if you are having problems with gmail on your symbian device saying “this program requires a working data connection”

then

change your access point eg using the E71 or E72, and I changed it by going through these steps:

Installations -> App. Mgr. -> Select Gmail -> Click Open -> Go to Access Point.

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By admin, July 29, 2010 10:53 PM

If you want to debrand the Optus E71

or are just generally fuicked off that you cant update the firmware

Simple change the product code of the phone to an unbranded one and then use nokia’s own software update service to update your phones firmware.

1) get the

2) Nemesis Service Suite
This is an application that actually does the changing of the product code. It can (preferably) be downloaded from the maker’s site BPreaks.brinkster.net for the latest version. (left hand side, downloads section)

3) change your product code from xxxxxxxx to xxxxxxxxxx using

NOKIA FIRMWARE FINDER-BEST TOOL

est tool for search the latest firmware your nokia.
Easy to use just 4 step
- choose nokia type (ex. E63 RM-437)
- select the latest firmware are available
- select firmware release for your country
- select firmware do you need (ex. only mcu, ppm or complete)
download

5) then use the Nokia Software Updater to update the firmware to the new phones correct firmware